Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity.
نویسندگان
چکیده
Acrylic copolymers with appropriate compositions of counits having cationic charge with 2-carbon and 6-carbon spacer arms can show superior antibacterial activities with concomitant very low hemolytic effect. These amphiphilic copolymers represent one of the most promising synthetic polymer antibacterial systems reported.
منابع مشابه
Effect of Relative Arrangement of Cationic and Lipophilic Moieties on Hemolytic and Antibacterial Activities of PEGylated Polyacrylates
Synthetic amphiphilic polymers have been established as potentially efficient agents to combat widespread deadly infections involving antibiotic resistant superbugs. Incorporation of poly(ethylene glycol) (PEG) side chains into amphiphilic copolymers can reduce their hemolytic activity while maintaining high antibacterial activity. Our study found that the incorporation of PEG has substantially...
متن کاملTuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives.
Amphiphilic cationic polynorbornene derivatives, soluble in water, were prepared from modular norbornene monomers, with a wide range of molecular weights (M(n) = 1600-137 500 g/mol) and narrow polydispersities (PDI = 1.1-1.3). The antibacterial activity determined by growth inhibition assays and the hemolytic activity against human red blood cells were measured and compared to determine the sel...
متن کاملAmphiphilic Polymers with Potent Antibacterial Activity
A general strategy is summarized for the assembly of polar and nonpolar domains into a modular monomer structure. Living ring-opening metathesis polymerization (ROMP) of these monomers provides access to a large range of molecular weights with narrow molecular weight distributions. The character and size of each domain can be tuned independently and locked into the repeating unit of the amphiph...
متن کاملBiological activities of C-terminal 15-residue synthetic fragment of melittin: design of an analog with improved antibacterial activity.
Melittin, the 26-residue predominant toxic peptide from bee venom, exhibits potent antibacterial activity in addition to its hemolytic activity. The synthetic peptide of 15 residues corresponding to its C-terminal end (MCF), which encompasses its most amphiphilic segment, is now being shown to possess antibacterial activity about 5-7 times less compared to that of melittin. MCF, however, is 300...
متن کاملPurification and Characterization of an Antibacterial, Antifungal and Non Hemolytic Peptide from Rana Ridibunda
Amphibians have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. A novel peptide with antibacterial effects and without hemolytic activity was purified from skin secretions of Rana ridibunda by multisteps cation-exchange FPLC, revers...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 50 53 شماره
صفحات -
تاریخ انتشار 2014